New and Emerging Treatment Options in Chronic Myeloid Leukemia General Information Requirements for Successful Completion: In order to receive credit, participants must view 4 audio-visual presentation(s) and fill out the post-test and evaluation forms. There are no costs for participating in this activity and receiving CME/CE credit. Certificates are awarded online after successful completion of the post-test and evaluation. Media:        Internet Release Date:        August 1, 2006 Expiration Date:        July 31, 2007 Estimated time to complete activity:        60 minutes Sponsorship:        This CME/CE activity is jointly sponsored by the University of Michigan Medical School, Amedco, LLC and PVI, PeerView Institute for Medical Education. Support:        This activity is supported by an educational grant from Bristol-Myers Squibb Company. Faculty Course Director and Interviewee Jorge Cortes, MD Professor of Medicine Deputy Chair, Department of Leukemia The University of Texas M. D. Anderson Cancer Center Houston, Texas Interviewees Susan M. O'Brien, MD Professor of Medicine Department of Leukemia The University of Texas M. D. Anderson Cancer Center Houston, Texas Neil P. Shah, MD, PhD Assistant Professor Division of Hematology and Oncology University of California, San Francisco School of Medicine San Francisco, California Moshe Talpaz, MD Professor of Internal Medicine Associate Chief/Director of Hematologic Malignancies Division of Hematology/Oncology University of Michigan Ann Arbor, Michigan CME Reviewer Harry P. Erba, MD, PhD Clinical Associate Professor of Internal Medicine Department of Internal Medicine Hematology & Oncology Division University of Michigan Medical School Ann Arbor, Michigan CE Reviewers Katie Spong, RN, LSW University of Minnesota Home Health Care St. Paul, Minnesota Kristine Kemp, RN Abbott-Northwestern Hospital Minneapolis, Minnesota Alexis Houck, RN, MA Health Partners Minneapolis, Minnesota Faculty Disclosures/Conflict of Interest Policy The University of Michigan Medical School has a conflict of interest policy that requires course faculty to disclose any real or apparent commercial financial affiliations related to the content of their presentations/materials. It is not assumed that these financial interests or affiliations will have an adverse impact on faculty presentations; they are simply noted here to fully inform participants. Jorge Cortes, MD, has a financial interest/relationship or affiliation in the form of: Grant/Research Support from Breakthrough Therapeutics, LLC; Bristol-Myers Squibb Company; ChemGenex Therapeutics, Inc.; and Novartis Pharmaceuticals Corporation. Speakers Bureau participant with Celgene Corporation and Novartis Pharmaceuticals Corporation. Susan M. O'Brien, MD, has a financial interest/relationship or affiliation in the form of: Grant/Research Support from Berlex, Inc.; Biogen Idec Inc.; and Genentech, Inc. Neil P. Shah, MD, PhD, has a financial interest/relationship or affiliation in the form of: Consultant for Bristol-Myers Squibb Company. Moshe Talpaz, MD, has a financial interest/relationship or affiliation in the form of: Grant/Research Support from Bristol-Myers Squibb Company and Novartis Pharmaceuticals Corporation. Speakers Bureau participant with Bristol-Myers Squibb Company and Novartis Pharmaceuticals Corporation. CME Reviewer: Harry P. Erba, MD, PhD, currently has no financial interests/relationships or affiliations in relation to this activity. Disclosure of Unlabeled Use The faculty of this educational activity may include discussions of products or devices that are not currently labeled for use by the FDA. Faculty members have been advised to disclose to the audience any reference to an unlabeled or investigational use. No endorsement of unapproved products or uses is made or implied by coverage of these products or uses in our reports. No responsibility is taken for errors or omissions in reports. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. Target Audience This activity has been designed to meet the educational needs of oncologists, hematologists, and oncology nurses. Program Description In this activity, experts in the treatment of chronic myeloid leukemia (CML) present recent data on the efficacy and safety of current and emerging targeted therapies. The use of the newer agents in advanced CML is highlighted. The mechanism for the development of resistance in CML is featured. Educational Objectives Upon completion of this activity, participants will be able to:   •  List current treatment options in CML and their benefits and limitations   •  Identify mechanisms of drug resistance in CML   •  Describe the molecular mechanisms of current and emerging targeted agents for CML   •  Review clinical trial results evaluating the efficacy and safety of current and emerging treatment options in CML   •  Outline current challenges in the management of CML   •  Evaluate strategies to overcome drug resistance in CML   •  Assess areas of ongoing research in CML and their potential impact on management of the disease Accreditation and Credit Designation Statements Physicians This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the University of Michigan Medical School and PVI, PeerView Institute for Medical Education. The University of Michigan Medical School is accredited by the ACCME to provide continuing medical education for physicians. The University of Michigan Medical School designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity. Nurses This course is co-provided by Amedco, LLC and PVI, PeerView Institute for Medical Education. Amedco, LLC, St. Paul, MN, is an approved provider of nursing continuing education by the Wisconsin Nurses Association Continuing Education Approval Program Committee, an accredited approver by the American Nurses Credentialing Center's Commission on Accreditation. 1.2 contact hour(s). Click here to fill out the evaluation form and post-test. Hardware/Software Requirements PeerView Press requires version 6.x browsers or higher from Microsoft or Netscape. Certain activities may require additional software to view. 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